Antifreeze Polypeptide (AFP) (HPLC-6), Winter Flounder( ——— )

Catalog No. M42055 CAS No. 122604-16-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Antifreeze Polypeptide (AFP) (HPLC-6), Winter Flounder
Note

Research use only, not for human use.
Brief Description

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei.
Description

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei.
In Vitro

Antifreeze Polypeptide 6 (winter flounder) inhibits the growth of ice crystals by hydrogen bonding of Thr, Asn, and Asp side chains in a specific pattern to the hexagonal bipyramidal planes of ice. This mode of binding is unidirectional, maximizing opportunities for packing of AFPs on the ice surface, and that ice crystal growth inhibition occurs by a two-step mechanism involving hydrogen bonding and hydrophobic interpeptide interactions.
In Vivo

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Synonyms

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Pathway

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Target

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Recptor

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Research Area

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Indication

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1. Wen D, et al. A model for binding of an antifreeze polypeptide to ice. Biophys J. 1992 Dec;63(6):1659-62.?

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